Tag Archives: Dementia

Brain Injury #Concussion

Flyers available from the main foyer display at Dunedin Hospital:

[click to enlarge]

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### ODT Online Sat, 25 Mar 2017
Editorial: Using your head over concussion
OPINION It is the headache that will not go away. Concussion in sport is again in the headlines and has, sadly, shown the vast difference in how two high-impact codes, rugby and league, handle the issue and the welfare of their players. […] It has taken a long time for sports bodies to accept the full impact of concussion. In years gone by it was considered “a knock to the head” and players were encouraged to get back on their feet and into the game. Last year, The New Zealand Herald wrote a compelling series about the long-term effect of head knocks in sport. It discovered five cases of dementia among the successful Taranaki rugby side of 1964, which their families attributed to concussion during their playing days. […] The NZRU this year launched a blue card initiative, which is aimed at getting concussed players off the field. The blue card can be issued when a referee suspects a player has suffered a concussion. The player must immediately stand down for at least three weeks, and obtain medical clearance to return to play.
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[2016 concussion series at nzherald.co.nz]
The Longest Goodbye: Rugby and the Dementia Dilemma

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### NZ Herald 5:00 AM Sun, 26 Mar 2017
New study finds stronger necks mean fewer concussions
By Kirsty Wynn – Herald on Sunday
Rugby coaches are being urged to concentrate on improving players’ neck strength in a bid to avoid debilitating concussions. A ground-breaking New Zealand study has found players with weaker and uneven neck strength are more vulnerable to severe impacts that may cause concussion. The experiment by Otago University’s Dr Hamish Osborne and Research Fellow Dr Danielle Salmon used bluetooth sensors behind the ears of 23 players in the Otago Mitre 10 Cup rugby team to measure acceleration, or g forces, during impacts in five games. The neck strength of each player was also measured using especially designed equipment. Salmon said the weaker the neck the more severe the damaging “whip-lash” type movement. A higher acceleration force was also recorded.
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Posted by Elizabeth Kerr

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Dementia research : Clearing sticky plaques from the brain

Amyloid-Plaques-and-Neurons-in-the-Brain-by-Juan-Gartner [psypost.org]Amyloid Plaques and Neurons in the Brain. Image: Juan-Gartner [psypost.org] – also reproduced by ScientificAmerica.com Story Link

A L Z H E I M E R S ● D I S E A S E

Since it was first identified more than a century ago, we still have no cure for Alzheimer’s disease. Among the various avenues that researchers have been working on to try and understand the causes and potential treatments for the disease, the role of blood vessels has been increasingly a focus – and in particular the “blood-brain barrier”, a protective layer of cells that regulates what can enter the brain through the blood. The blood-brain barrier is usually very tight in young, healthy people. This means that the brain controls what substances get in, which is important for proper brain function. However, this high level of control can be a problem for treating brain diseases because drugs in the bloodstream can be kept out of the brain. A lot of research is being done to try get around this problem […] As well as acting as a gatekeeper for entry of substances into the brain, the blood-brain barrier is important for removing waste products from the brain. One of these products, β-amyloid, is a key player in Alzheimer’s disease.

β-amyloid is made in the brains of everyone. In the healthy brain, it is quickly removed from the brain by moving across the blood-brain barrier into the blood. In the old brain, this movement is slower and allows β-amyloid to build up. And as it builds up, β-amyloid causes damage to both the brain and the blood-brain barrier, which in turn creates further damage by decreasing the removal of β-amyloid from the brain and allowing entry of toxins from the blood.

This on-going cycle of damage is thought to contribute to the development of Alzheimer’s disease.

Source: PsyPost : Slowdown of brain’s waste removal system could drive Alzheimer’s (17.3.15)

PsyPost is a psychology and neuroscience news website dedicated to reporting the latest research on human behaviour, cognition, and society. The publication covers the latest discoveries in psychology, psychiatry, neuroscience, sociology and similar fields, featuring news releases from universities and other organisations, along with original reporting on undernoticed studies.

β-amyloid oligomers (red) and receptor LilrB2 or PirB (green) in neuronal synapses of Alzheimer’s brains. [medicalxpress.com]Artist rendering: β-amyloid oligomers (red) and receptor LilrB2 or PirB (green) in neuronal synapses of Alzheimer’s brains. [medicalxpress.com]

Scientists at the Stanford University School of Medicine have shown how a protein fragment known as beta-amyloid, strongly implicated in Alzheimer’s disease, begins destroying synapses before it clumps into plaques that lead to nerve cell death.

Source: MedicalExpress.com : Scientists reveal how beta-amyloid may cause Alzheimer’s (19.9.13)

### msn.com Fri, 2 Sep 2016 8 hrs ago
Alzheimer’s: New drug that halts mental decline is ‘best news for dementia in 25 years’
By Sarah Knapton, Science Editor – The Telegraph (UK)
The first drug that can prevent Alzheimer’s disease is finally on the horizon after scientists proved they can clear the sticky plaques from the brain which cause dementia and halt mental decline. Hailed as the “best news” in dementia research for 25 years, the breakthrough is said to be a potential “game changer” for people with Alzheimer’s.

The red marks show amyloid plaques but after a year they are gone in the highest dose group. [via telegraph.co.uk]The red marks show amyloid plaques but after a year they are gone in the highest dose group. [telegraph.co.uk]

Scientists said they were amazed to find that patients treated with the highest dose of the antibody drug aducanumab experienced an almost complete clearance of the amyloid plaques that prevent brain cells communicating, leading to irreversible memory loss and cognitive decline.

Crucially they also found that after six months of the treatment, patients stopped deteriorating compared with those taking a placebo, suggesting that their dementia had been halted. If shown to be effective in larger trials, the first drug to prevent dementia could be available in just a few years.

“The results of this clinical study make us optimistic that we can potentially make a great step forward in treating Alzheimer’s disease,” said Prof Roger Nitsch, at the Institute for Regenerative Medicine at the University of Zurich. In the high dose group the amyloid has almost completely disappeared. The effect size of this drug is unprecedented. Despite it being a small sample there appeared to be a slowing of cognitive decline and functional decline. The group with a high degree of amyloid removal were basically stable. If we could reproduce this it would be terrific.”
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Source: (via paywall) http://www.telegraph.co.uk/science/2016/09/01/alzheimers-new-drug-that-halts-mental-decline-is-best-news-for-d/

Posted by Elizabeth Kerr

Election Year. This post is offered in the public interest.

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Bleeding hearts of ODT #DeathofaCitybyCull

F R I G G I N G ● P O P P Y C O C K ● I N ● E L E C T I O N ● Y E A R

a rudimentary discourse

### ODT Online Mon, 18 Jul 2016
Editorial: Dunedin’s growing contentment
OPINION It is time to consign Dunedin’s habitual discontent to history…. Link
[IF YOU MEAN IT – STOP SUPPORTING MAYOR CULL]

OPINION For a time our weather, isolation, strong links to the supposedly dour Scots and misery at our falling fortunes served as excuses….
[IF YOU MEAN IT – VOTE OUT CULL]

OPINION The University of Otago’s success in many ways saved the city yet, ironically, helped solidify its bleak reputation as students from around the country were met by old, cold and damp houses in a city down on luck and struggling to rediscover its place in the world.
[MAYOR OF DUNEDIN NO LONGER SITS ON UNIVERSITY COUNCIL]

OPINION This time the stories are all positive. […] And why wouldn’t they be?
[PSST. CULL’S COUNCIL DROWNS SOUTH DUNEDIN JUNE 2015]

OPINION The city boasts extraordinary infrastructure….
[DAMAGES TO SOUTH DUNEDIN, YEARS OF BLOCKED DRAINS TENS OF MILLIONS OF DOLLARS LATER]

OPINION No other city in the country has anything to rival Forsyth Barr Stadium….
[53,000 AGING RATEPAYERS, DESCENDENTS AND NEWCOMERS PAYING OFF DCC CONSOLIDATED DEBT FOREVER]

OPINION At the same time Auckland’s famed sunny summers have been accompanied in recent years by concerns around swarms of houseflies, jellyfish, sea lice and mosquitoes, nuisances unheard of here.
[GET FREAKING REAL, TAKEN LEAVE OF YOUR SENSES ?]

OPINION The current upsurge for Dunedin may not be a boom of mythical proportion with gold ingots springing from the soil.
[VERY NEARLY IS, MYTHICAL AND DREAR WHILE CULL WEARS CHAIN]

—Trite and tarnished, tissue of UNtruths.
SMITH BROS : HELP VOTE CULL OUT

Deceits and Dementia at Dunedin, anyone ?

#DUD

Posted by Elizabeth Kerr

Waves-ocean-water + dave deleted[clipartix.com + whatifdunedin]

Election Year. This post is offered in the public interest.

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